MEYS, Projects of Large Research Infrastructures; reg. no. LM2023033; 2023–2026

Czech biobank network (BBMRI.cz)

Investigator: doc. Mgr. Roman Hrstka, Ph.D.

MEYS, P JAC; reg. no.: CZ.02.01.01/00/23_015/0008196; 04/2024–12/2026

Development and Modernisation of the National Biobank Network (BBMRInv)

Investigator: doc. Mgr. Roman Hrstka, Ph.D.

MEYS, INTER-EXCELLENCE II; reg. no. LUC23033; 09/2023–09/2025

The effects of radiation and hypoxia on head and neck cancer cells shaping the neutrophil heterogeneity

Co-investigator: doc. Mgr. Roman Hrstka, Ph.D.

EU, Horizon 2020 (H2020-SC1-BHC-2018-2020); grant agreement no.: 825410; 01/2019–06/2024

Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response (ONCOBIOME)

Co-investigator: RNDr. Bc. Iveta Selingerová, Ph.D.

EU, Horizon 2020 (H2020-WIDESPREAD-2018-2020); grant agreement no.: 857560; 01/2020–12/2026

Delving deeper into the study of environment effects on human health (CETOCOEN Excellence)

Co-investigator: doc. Mgr. Roman Hrstka, Ph.D.

EU, European Cooperation in Science and Technology (COST); grant agreement no.: CA20117; 10/2021–10/2025

Converting molecular profiles of myeloid cells into biomarkers for inflammation and cancer (Mye-InfoBank)

Co-investigator: doc. Mgr. Roman Hrstka, Ph.D.

EU, Horizon Europe (HORIZON-INFRA-2021-SERV-01-01); grant agreement no. 101058620; 2022–2025

Providing cutting edge cancer research services across Europe (canSERV)

Co-investigator: doc. Mgr. Roman Hrstka, Ph.D.

EU, Horizon Europe (HORIZON-INFRA-2023-DEV-01); ID: 101131701; 02/2024–12/2026

Accelerating datafication for support of EU health priorities, greening of biobanks and integrated approach to “One Health” (EvolveBBMRI)

Co-investigator: doc. Mgr. Roman Hrstka, Ph.D.

Bartosik M, Moranova L, Izadi N, Strmiskova J, Sebuyoya R, Holcakova J, Hrstka R. Advanced technologies towards improved HPV diagnostics. J Med Virol. 2024 Feb;96(2):e29409. doi: 10.1002/jmv.29409. (IF2023: 6,8; Q1)

Benesova I, Nenutil R, Urminsky A, Lattova E, Uhrik L, Grell P, Kokas FZ, Halamkova J, Zdrahal Z, Vojtesek B, Novotny MV, Hernychova L. N-glycan profiling of tissue samples to aid breast cancer subtyping. Sci Rep. 2024 Jan 3;14(1):320. doi: 10.1038/s41598-023-51021-3. (IF2023: 3,8; Q1)

Burkon P, Selingerova I, Slavik M, Holanek M, Vrzal M, Coufal O, Polachova K, Muller P, Slampa P, Kazda T. Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study. Radiat Oncol. 2024 Feb 3;19(1):17. doi: 10.1186/s13014-024-02412-x. (IF2023: 3,3; Q1)

Fadrus J, Vybíhal V, Roskova I, Selingerová I, Smrcka M, Jancalek R, Šána J, Slabý O, Pospíšil P, Hynková L, Garčic J, Belanová R, Křístek J, Sprlakova-Pukova A, Mackerle Z, Juran V, Sova M, Neuman E, Valekova H, Lakomý R, Holánek M, Hrstka R, Svajdova M, Poláchová K, Kolouskova I, Šlampa P, Kazda T. Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice. Rep Pract Oncol Radiother. 2024;29(1):30-41. doi: 10.5603/rpor.99362. (IF2023: 1,2; Q3)

Hamala V, Ondrášková K, Červenková Šťastná L, Krčil A, Müllerová M, Kurfiřt M, Hiršová K, Holčáková J, Gyepes R, Císařová I, Bernášková J, Hrstka R, Karban J. Improving the anticancer activity of fluorinated glucosamine and galactosamine analogs by attachment of a ferrocene or ruthenium tetrazene motif. Appl Organomet Chem. 2024;38(5):e7399. doi: 10.1002/aoc.7399. (IF2023: 3,7; Q2)

Holikova K, Selingerova I, Pospisil P, Bulik M, Hynkova L, Kolouskova I, Hnidakova L, Burkon P, Slavik M, Sana J, Holecek T, Vanicek J, Slampa P, Jancalek R, Kazda T. Hippocampal subfield volumetric changes after radiotherapy for brain metastases. Neurooncol Adv. 2024 Mar 20;6(1):vdae040. doi: 10.1093/noajnl/vdae040. (IF2023: 3,7; Q1)

Jochmanová E, Nováková K, Růčková E, Hrstka R. České biobanky - zdroj kvalitního biologického materiálu. Florence 2014;20(2):84-86. (bez IF)

Peterka O, Maccelli A, Jirásko R, Vaňková Z, Idkowiak J, Hrstka R, Wolrab D, Holčapek M. HILIC/MS quantitation of low-abundant phospholipids and sphingolipids in human plasma and serum: Dysregulation in pancreatic cancer. Anal Chim Acta. 2024 Feb 1;1288:342144. doi: 10.1016/j.aca.2023.342144. (IF2023: 5,7; Q1)

Povedano E, Ruiz-Valdepeñas Montiel V, Sebuyoya R, Torrente-Rodríguez RM, Garranzo-Asensio M, Montero-Calle A, Pingarrón JM, Barderas R, Bartosik M, Campuzano S. Bringing to Light the Importance of the miRNA Methylome in Colorectal Cancer Prognosis Through Electrochemical Bioplatforms. Anal Chem. 2024 Feb 13;96(11):4580–4588. doi: 10.1021/acs.analchem.3c05474. (IF2023: 6,7; Q1)

Selingerova I, Holikova K, Chodur T, Hynkova L, Pospisil P, Bulik M, Belanova R, Siffelova K, Kolouskova I, Slavik M, Burkon P, Hrstka R, Jancalek R, Sana J, Slampa P, Kazda T. Challenges with hippocampal MR spectroscopy as a surrogate for pre-radiotherapy assessment of neurocognitive impairment in patients with brain metastasis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024 Apr 15. doi: 10.5507/bp.2024.012. Epub ahead of print. (IF2023: 0,7; Q4)

Vychytilova-Faltejskova P, Vilmanova S, Pifkova L, Catela Ivković T, Mᶏdrzyk M, Jugas R, Machackova T, Kotoucek J, Sachlova M, Bohovicova L, Stanek T, Halamkova J, Kiss I, Slaby O. Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples. Clin Chem Lab Med. 2024 Jul 31;62(1):157-167. doi: 10.1515/cclm-2023-0610. (IF2023: 3,8; Q1)

Bohosova J, Kozelkova K, Al Tukmachi D, Trachtova K, Naar O, Ruckova M, Kolarikova E, Stanik M, Poprach A, Slaby O. Long non-coding RNAs enable precise diagnosis and prediction of early relapse after nephrectomy in patients with renal cell carcinoma. J Cancer Res Clin Oncol. 2023 Aug;149(10):7587-7600. doi: 10.1007/s00432-023-04700-7. (IF2022: 3,6; Q2)

Gallo M, Krajňanský V, Nenutil R, Holub P, Brázdil B. Shedding Light on the Black Box of a Neural Network Used to Detect Prostate Cancer in Whole Slide Images by Occlusion-Based Explainability. N Biotechnol. 2023 Oct 2;78: 52-67. doi: 10.1016/j.nbt.2023.09.008. (IF2022: 5,4; Q1)

Grell P, Borilova S, Fabian P, Selingerova I, Novak D, Muller P, Kiss I, Vyzula R. FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer. Cancers (Basel). 2023 Mar 22;15(6):1901. doi: 10.3390/cancers15061901. (IF2022: 5,2; Q2)

Halámková J, Bohovicová L, Pehalová L, Kazda T, Goněc R, Staněk T, Mouková L, Adámková Krákorová D, Kozáková Š, Svoboda M, Demlová R, Gabrielová L, Hernychová L, Kiss I. The risk of second primary malignancies in colorectal cancer patients using calcium channel blockers. Sci Rep. 2023 Mar 1;13(1):3490. doi: 10.1038/s41598-023-29535-7. (IF2022: 4,6; Q2)

Holub P, Müller H, Bíl T, Pireddu L, Plass M, Prasser F, Schlünder I, Zatloukal K, Nenutil R, Brázdil T. Privacy risks of whole-slide image sharing in digital pathology. Nat Commun. 2023 May 4;14(1):2577. doi: 10.1038/s41467-023-37991-y. (IF2022: 16,6; Q1)

Idkowiak J, Jirásko R, Kolářová D, Bártl J, Hájek T, Antonelli M, Vaňková Z, Wolrab D, Hrstka R, Študentová H, Melichar B, Pešková K, Holčapek M. Robust and high-throughput lipidomic quantitation of human blood samples using flow injection analysis with tandem mass spectrometry for clinical use. Anal Bioanal Chem. 2023 Feb;415(5):935-951. doi: 10.1007/s00216-022-04490-w. (IF2022: 4,3; Q1)

Kral J, Jelinkova S, Zemankova P, Vocka M, Borecka M, Cerna L, Cerna M, Dostalek L, Duskova P, Foretova L, Havranek O, Horackova K, Hovhannisyan M, Chvojka S, Kalousova M, Kosarova M, Koudova M, Krutilkova V, Machackova E, Nehasil P, Novotny J, Otahalova B, Puchmajerova A, Safarikova M, Slama J, Stranecky V, Subrt I, Tavandzis S, Zikan M, Zima T, Soukupova J, Kleiblova P, Kleibl Z, Janatova M. Germline multigene panel testing of patients with endometrial cancer. Oncol Lett. 2023 Apr 12;25(6):216. doi: 10.3892/ol.2023.13802. (IF2022: 2,9; Q3)

Moráňová L, Bartošík M, Strmisková J, Nováková K. Elektrochemická analýza klinických vzorků – cesta k translačnímu výzkumu. Chem. Listy 2023;117(10):595-603. doi: 10.54779/chl20230595. (IF2022: 0,6; Q4)

Ondraskova K, Sebuyoya R, Moranova L, Holcakova J, Vonka P, Hrstka R, Bartosik M. Electrochemical biosensors for analysis of DNA point mutations in cancer research. Anal Bioanal Chem. 2023 Mar;415(6):1065-1085. doi: 10.1007/s00216-022-04388-7. (IF2022: 4,3; Q1)

Sebuyoya R, Valverde A, Moranova L, Strmiskova J, Hrstka R, Ruiz-Valdepeñas Montiel V, Pingarrón JM, Barderas R, Campuzano S, Bartosik M. Dual detection system for cancer-associated point mutations assisted by a multiplexed LNA-based amperometric bioplatform coupled with rolling circle amplification. Sens Actuators B Chem. 2023; 394:134375. doi: 10.1016/j.snb.2023.134375. (IF2022: 8,4; Q1)

Vonka P, Rarova L, Bazgier V, Tichy V, Kolarova T, Holcakova J, Berka K, Kvasnica M, Oklestkova J, Kudova E, Strnad M, Hrstka R. Small change - big consequence: The impact of C15-C16 double bond in a D‑ring of estrone on estrogen receptor activity. J Steroid Biochem Mol Biol. 2023 Oct;233:106365. doi: 10.1016/j.jsbmb.2023.106365. (IF2022: 4,1; Q2)

Bouchalova P, Sommerova L, Potesil D, Martisova A, Lapcik P, Koci V, Scherl A, Vonka P, Planas-Iglesias J, Chevet E, Bouchal P, Hrstka R. Characterization of the AGR2 interactome uncovers new players of Protein Disulfide Isomerase network in cancer cells. Mol Cell Proteomics 2022:21(2):100188. doi: 10.1016/j.mcpro.2021.100188. (IF2021: 7,381; Q1)

Burkoň P, Trna J, Slávik M, Němeček R, Kazda T, Pospíšil P, Dastych M, Eid M, Novotný I, Procházka T, Vrzal M. Stereotactic Body Radiotherapy (SBRT) of Pancreatic Cancer-A Critical Review and Practical Consideration. Biomedicines. 2022 Oct 4;10(10):2480. doi: 10.3390/biomedicines10102480. (IF2021: 4,757; Q2)

Brázdil T, Gallo M, Nenutil R, Kubanda A, Toufar M, Holub P. Automated annotations of epithelial cells and stroma in hematoxylin-eosin-stained whole-slide images using cytokeratin re-staining. J Pathol Clin Res. 2022 Mar;8(2):129-142. doi: 10.1002/cjp2.249. (IF2021: 4,373; Q1)

Halámková J, Bohovicová L, Pehalová L, Goněc R, Staněk T, Kazda T, Mouková L, Krákorová DA, Kozáková Š, Svoboda M, Demlová R, Kiss I. Use of Hypolipidemic Drugs and the Risk of Second Primary Malignancy in Colorectal Cancer Patients. Cancers (Basel). 2022 Mar 27;14(7):1699. doi: 10.3390/cancers14071699. (IF2021: 6,575; Q1)

Holanek M, Selingerova I, Fabian P, Coufal O, Zapletal O, Petrakova K, Kazda T, Hrstka R, Poprach A, Zvarikova M, Bilek O, Svoboda M. Biomarker Dynamics and Long-Term Treatment Outcomes in Breast Cancer Patients with Residual Cancer Burden after Neoadjuvant Therapy. Diagnostics (Basel). 2022 Jul 18;12(7):1740. doi: 10.3390/diagnostics12071740. (IF2021: 3,992; Q1)

Moranova L, Stanik M, Hrstka R, Campuzano S, Bartosik M. Electrochemical LAMP-based assay for detection of RNA biomarkers in prostate cancer. Talanta 2022; 238(Part 2):123064. doi: 10.1016/j.talanta.2021.123064. (IF2021: 6,556; Q1)

Obermannova R, Selingerova I, Rehak Z, Jedlicka V, Slavik M, Fabian P, Novotny I, Zemanova M, Studentova H, Grell P, Zdrazilova Dubska L, Demlova R, Harustiak T, Hejnova R, Kiss I, Vyzula R. PET/CT-tailored treatment of locally advanced oesophago-gastric junction adenocarcinoma: a report on the feasibility of the multicenter GastroPET study. Ther Adv Med Oncol. 2022 Jan 5;13:17588359211065153. doi: 10.1177/17588359211065153. (IF2021: 8,168; Q1)

Rihacek M, Selingerova I, Kocak I, Kocakova I, Rihackova E, Valik D, Sterba J. Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients. Curr Oncol. 2022 Jun 7;29(6):4138-4147. doi: 10.3390/curroncol29060330. (IF2021: 3,109; Q3)

Sebuyoya R, Moranova L, Izadi N, Moran L, Hrstka R, Anton M, Bartosik M. Electrochemical DNA biosensor coupled to LAMP reaction for early diagnostics of cervical precancerous lesions. Biosens Bioelectron X 2022;12:100224. doi: 10.1016/j.biosx.2022.100224. (bez IF; Q1)

Wolrab D, Jirásko R, Cífková E, Höring M, Mei D, Chocholoušková M, Peterka O, Idkowiak J, Hrnčiarová T, Kuchař L, Ahrends R, Brumarová R, Friedecký D, Vivo-Truyols G, Škrha P, Škrha J, Kučera R, Melichar B, Liebisch G, Burkhardt R, Wenk MR, Cazenave-Gassiot A, Karásek P, Novotný I, Greplová K, Hrstka R, Holčapek M. Lipidomic profiling of human serum enables detection of pancreatic cancer. Nat Commun. 2022 Jan 10;13(1):124. doi: 10.1038/s41467-021-27765-9. (IF2021: 17,694; Q1)

Galoczova, M., Nenutil, R., Pokorna, Z., Vojtesek, B., Coates, P.J. TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis. Virchows Arch 2021;478(4):627-636. doi: 10.1007/s00428-020-02944-z. (IF2020: 4,064; Q2)

Halamkova, J., Kazda, T., Pehalova, L., Gonec, R., Kozakova, S., Bohovicova, L., Adamkova Krakorova, D., Slaby, O., Demlova, R., Svoboda, M., Kiss, I. Second primary malignancies in colorectal cancer patients. Sci Rep 2021;11(1):2759. doi: 10.1038/s41598-021-82248-7. (IF2020: 4,380; Q1)

Halamkova, J., Kazda, T., Pehalova, L., Gonec, R., Kozakova, S., Bohovicova, L., Slaby, O., Demlova, R., Svoboda, M., Kiss, I. The Impact of Diabetes Mellitus on the Second Primary Malignancies in Colorectal Cancer Patients. Front Oncol 2021;10:573394. doi: 10.3389/fonc.2020.573394. (IF2020: 6,244; Q2)

Holanek, M., Selingerova, I., Bilek, O., Kazda, T., Fabian, P., Foretova, L., Zvarikova, M., Obermannova, R., Kolouskova, I., Coufal, O., Petrakova, K., Svoboda, M., Poprach, A. Neoadjuvant Chemotherapy of Triple-Negative Breast Cancer: Evaluation of Early Clinical Response, Pathological Complete Response Rates, and Addition of Platinum Salts Benefit Based on Real-World Evidence. Cancers (Basel) 2021;13(7):1586. doi: 10.3390/cancers13071586.  (IF2020: 6,639; Q1)

Holcakova, J., Bartosik, M., Anton, M., Minar, L., Hausnerova, J., Bednarikova, M., Weinberger, V., Hrstka, R. New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers. Cancers (Basel). 2021 Dec 17;13(24):6339. doi: 10.3390/cancers13246339. (IF2020: 6,639; Q1)

Izadi, N., Sebuyoya, R., Moranova, L., Hrstka, R., Anton, M., Bartosik, M. Electrochemical bioassay coupled to LAMP reaction for determination of high-risk HPV infection in crude lysates. Anal Chim Acta. 2021 Dec 1;1187:339145. doi: 10.1016/j.aca.2021.339145. (IF2020: 6,558; Q1)

Selingerova, I., Valik, D., Gescheidtova, L., Sramek, V., Cermakova, Z., Zdrazilova-Dubska, L. Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI. J Med Virol 2021;93(3):1805-1809. doi: 10.1002/jmv.26612. (IF2020: 2,327; Q4) 

Selingerova, I., Katina, S., Horova, I. Comparison of parametric and semiparametric survival regression models with kernel estimation. J Stat Comput Sim 2021;91(13):2717-2739. doi: 10.1080/00949655.2021.1906875. (IF2020: 1,424; Q4)

Slavik, M., Burkon, P., Selingerova, I., Krupa, P., Kazda, T., Stankova, J., Nikl, T., Hejnova, R., Rehak, Z., Osmera, P., Prochazka, T., Dvorakova, E., Pospisil, P., Grell, P., Slampa, P., Obermannova, R. Preoperative Chemoradiotherapy for Gastroesophageal Junction Adenocarcinoma Modified by PET/CT: Results of Virtual Planning Study. Medicina (Lithuania Kaunas). 2021 Dec 6;57(12):1334. doi: 10.3390/medicina57121334. (IF2020: 2,430; Q2)

Zwinsová, B., Petrov, V.A., Hrivňáková, M., Smatana, S., Micenková, L., Kazdová, N., Popovici, V., Hrstka, R., Šefr, R., Bencsiková, B., Zdražilová-Dubská, L., Brychtová, V., Nenutil, R., Vídeňská, P., Budinská, E. Colorectal Tumour Mucosa Microbiome Is Enriched in Oral Pathogens and Defines Three Subtypes That Correlate with Markers of Tumour Progression. Cancers (Basel) 2021;13(19):4799. doi: 10.3390/cancers13194799. (IF2020: 6,639; Q1)

Holub, P., Kozera, L., Florindi, F., Van Enckevort, E., Swert, M., Reihs, R., Wutte, A., Valík, D., Mayrhofer, M.T. BBMRI-ERIC COMMUNITY, BBMRI-ERIC's Contributions to Research and Knowledge Exchange on COVID-19. Eur J Hum Genet 2020;28(6):728-731. doi: 10.1038/s41431-020-0634-8. (IF2019: 3,540; Q1)

Kýr, M., Klement, G.L., Zdrazilova-Dubska, L., Demlova, R., Valik, D., Slaby, O., Slavc, I., Sterba, J. Editorial: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize. Front Oncol 2020;10:377. doi: 10.3389/fonc.2020.00377. (IF2019: 4,250; Q1)

Liu, Y., Nekulova, M., Nenutil, R., Horakova, I., Appleyard, M.V., Murray, K., Holcakova, J., Galoczova, M., Quinlan, P., Jordan, L.B., Purdie, C.A., Vojtesek, B., Thompson, A.M., Coates, P.J. ∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER+ and HER2+ breast cancers. J Pathol Clin Res 2020;6(1):83-93. doi: 10.1002/cjp2.149. (IF2019: 3,489; Q4)

Náležinská, M., Zdražilová Dubská, L., Valík, D., Hernychová, L., Pavlík, T., Mazalová, M., Chovanec, J., Fait, V. Úskalí laboratorních metod v ovariálním skríninku - doba "-omická"? Onkologie 2020;14(2):88-92. doi: 10.36290/xon.2020.016. (bez IF)

Silvestri, V., Foretova, L., Machackova, E.  et al. Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). JAMA Oncol 2020;6(8):1218-1230. doi: 10.1001/jamaoncol.2020.2134. (IF2019: 13,860; Q1)

Vyskočil, J. Kardiotoxicita onkologické léčby. Postgrad Med 2020;22(2):151-157. (bez IF)